CD28 Antikörper (PE)

Produktnummer ABIN371360

Der Maus Monoklonal Anti-CD28-Antikörper wurde für FACS validiert. Er ist geeignet, CD28 in Proben von Huhn und Pute zu detektieren.

Kurzübersicht für CD28 Antikörper (PE) (ABIN371360)

Target: CD28

Reaktivität: Huhn, Pute

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD28 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Klon: AV7

Produktdetails anti-CD28 Antikörper (PE)

Spezifität: This antibody recognizes Chicken CD28, a monomeric molecule of Mr 40-44 kDa with 50 % amino acid sequence identity with mammalian CD28.

Produktmerkmale: Synonyms: TP44, T-cell-specific surface glycoprotein CD28

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: < / = 0.2 μg/10^6 cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative and a stabilizing agent.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CD28

Target: CD28

Andere Bezeichnung: CD28

Hintergrund: Chicken CD28 antigen is a type I transmembrane monomeric glycoprotein which does not contain the cysteine residues that form disulfide-linked covalent homodimers found in the mammalian counterpart. This may reduce the avidity of binding to individual ligand molecules expected to be present on Ag presenting cells. Peripheral gamma/delta+ T cells are CD28-negative. (Ref.1) Monoclonal antibodies against CD28 have a costimulatory effect on T cells stimulated by phorbol myristate acetate (PMA), concanavalin A or MAbs against the avian T cell receptor (TCR). Both Vbeta1- and Vbeta2-expressing cells respond equally well to stimulation with anti-CD28 in combination with PMA. These responses are resistant to cyclosporin A, but inhibited by herbimycin A, suggesting that CD28 employs a signalling pathway at least partly distinct from that triggered by TCR/CD3. (Ref.2)Synonyms: T-cell-specific surface glycoprotein CD28, TP44

Gen-ID: 396249

UniProt: P31043

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response